Recombinant Human IL15RA/IL-15RA Protein (Fc Tag)

SKU: PKSH032566

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Cytokines

Abbreviation: IL15RA;IL-15RA

Target Synonym: MGC;IL15RA;CD215;alpha;CD215 antigen;IL-15 receptor subunit alpha;IL-15RA;IL-15R-alpha;interleukin 15 receptor;interleukin-15 receptor subunit alpha;MGC104179;AA690181;I15RA;IL 15R alpha;Interleukin 15 receptor alpha;Interleukin 15 receptor subunit alpha;sIL-15 receptor subunit alpha;sIL-15RA;sIL-15R-alpha;Soluble interleukin 15 receptor subunit alpha;Soluble interleukin-15 receptor subunit alpha

Research Areas: Signal Transduction;Cell biology;Cancer;metabolism;

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application: Cell culture

Fusion tag: C-Fc

UNIProt ID: Q13261

Accession: Q13261-3

Background: Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor β and γ heterodimers and enables signaling to cells.

Concentration:

Activity: Measured by its ability to block human IL-15-induced proliferation of CTLL‑2 mouse cytotoxic T cells. The ED₅₀ for this effect is 0.35-3.5 ng/ml.

Sequence: Ile31-Thr172

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 42.0 kDa

ObservedMW: 60-75 kDa