Recombinant Human IL-9 protein

SKU: CD01481

Size:2 ug

Background:Interleukin-9 (IL-9) is encoded by the IL9 gene and produced by T-cells and specifically by CD4+ helper cells. IL-9 was originally identified as a cytokine found in the conditioned medium of a human T cell leukemia virus type I (HTLVI) transformed T cell line. It functions through the IL-9 receptor, which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. IL-9 can support the growth of IL-2 independent and IL-4 independent helper T-cells. Human IL-9 has approximately 56 % amino acid sequence identity with Mouse IL-9. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Interleukin-9

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by a cell proliferation assay using human MO7e cells is less than .2 ng/ml, corresponding to a specific activity of > 5. × 16 IU/mg.

Synonyms:IL-9,HP4, IL-9, P4, Human

Endotoxin:Less than 1EU/μg of rHuIL-9 as determined by LAL method.

Storage:-20ºC

Sequence:QGCPTLAGIL DINFLINKMQ EDPASKCHCS ANVTSCLCLG IPSDNCTRPC FSERLSQMTN TTMQTRYPLI FSRVKKSVEV LKNNKCPYFS CEQPCNQTTA GNALTFLKSL LEIFQKEKMR GMRGKI

uniprot accession:P15248;Q6NZ74;Q6NZ75

Molecular weight:Approximately 14.1 kDa, a single non-glycosylated polypeptide chain containing 126 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.