Recombinant Human IL-29 protein(His Tag)

SKU: PKSH034114

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Cytokines

Abbreviation: IL-29

Target Synonym: IFN-lambda;Interleukin;ytokine Zcyto;Cytokine Zcyto;IFNL;ZCYTO;IFN-λ;lambda;Cytokine Zcyto21;IFN-lambda-1;IFN-λ1;IL-29;interferon;interferon lambda 1;Interferon lambda-1;Interleukin-29;lambda 1;ytokine Zcyto21;IL29;ZCYTO21;IFNL1

Research Areas: Immunology,Microbiology

Conjugation:

Target Species: Human

Expression Host: E.coli

Application: Cell culture

Fusion tag: C-His

UNIProt ID: Q8IU54

Accession: Q8IU54

Background: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Concentration:

Activity: Measure by its ability to induce IL-8 secretion in HuH7 cells. The ED₅₀ for this effect is <6 ng/mL.

Sequence: Pro 23-Thr 200

Purity: > 98 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS,pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method.

Calculated MW: 20.7 kDa

ObservedMW: 22 kDa