Recombinant Human IL-24 protein(His Tag)

SKU: PKSH034109

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Cytokines

Abbreviation: IL-24

Target Synonym: MDA;MOB;Melanoma Differentiation Association Protein;IL24;C49A;FISP;IL10B;MDA7;MOB5;ST16;MDA-7 (Melanoma Differentiation-Associated gene 7 protein);Melanoma Differentiation Association Protein 7;IL 24;IL 4 induced secreted protein;IL-24;interleukin 24;Interleukin-24;MDA-7;Melanocyte associated Mda 7;Melanoma differentiation-associated gene 7 protein;Suppression of tumorigenicity 16;Suppression of tumorigenicity 16 (melanoma differentiation);Suppression of tumorigenicity 16 protein

Research Areas: Immunology,Cancer

Conjugation:

Target Species: Human

Expression Host: E.coli

Application: Cell culture

Fusion tag: C-His

UNIProt ID: Q13007

Accession: Q13007

Background: Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I intereferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2.

Concentration:

Activity: Measure by its ability to chemoattract BaF3 cells transfected with human IL-20R alpha and IL-20R beta. The ED₅₀ for this effect is <120 pg/mL.

Sequence: Gln 52-Leu 206

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS,pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method.

Calculated MW: 19.1 kDa

ObservedMW: 17 kDa