Recombinant Human IL-22BP/IL22RA2 Protein (His & Fc Tag)

SKU: PKSH031301

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Cytokines

Abbreviation: IL-22BP/IL22RA2

Target Synonym: UNQ;Il22ra;IL22RA2;UNQ5793;PRO19598;PRO19822;Class II cytokine receptor;CRF2 10;CRF2 S1;CRF2-10;CRF2-S1;CRF2X;Cytokine receptor class II member 10;Cytokine receptor class-II member 10;Cytokine receptor family 2 member 10;Cytokine receptor family type 2;Cytokine receptor family type 2 soluble 1;I22R2;IL 22 receptor subunit alpha 2;IL 22BP;IL 22R alpha 2;IL 22RA2;IL-22 receptor subunit alpha-2;IL22BP;IL-22BP;IL22R alpha 2;IL-22RA2;IL-22R-alpha-2;Interleukin 22 binding protein;Interleukin 22 Receptor alpha 2;Interleukin-22 receptor subunit alpha-2;Interleukin-22-binding protein;MGC150509;MGC150510;soluble 1;ZcytoR16

Research Areas: immunology

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His-Fc

UNIProt ID: Q969J5

Accession: NP_851826.1

Background: Interleukin-22 receptor subunit alpha-2 (IL-22RA2); also known as interleukin-22-binding protein (IL-22BP); is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues; including those in the digestive; female reproductive; and immune systems. It is expressed in placenta; spleen; breast; skin and lung. It is also detected in intestinal tract; testis; brain; heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered; a membrane-bound receptor and a soluble receptor.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Pro 231

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 52.8 kDa

ObservedMW: 80-90 kDa