Recombinant Human IL-22 protein

SKU: CD01518

Size:2 ug

Background:IL-22 is belonging to IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes and dendritic cells, IL-10 contributes to the inflammatory response in vivo. IL-22 signals through CRF2-4 and IL-22. It along with IL-17 is rapidly produced by splenic LTi-like cells and can be also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive and innate immune systems.

Research_area:Immunology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Interleukin-22

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by inducing IL-1 secretion of human COLO 25 cells is less than .3 ng/ml, corresponding to a specific activity of > 3.3 × 16 IU/mg.

Synonyms:IL-22,IL-21, IL22, IL-D11, IL-TIF, ILTIF, TIFIL-23, TIFa, zcyto18, Human

Endotoxin:Less than 1 EU/μg of rHuIL-22 as determined by LAL method.

Storage:-20ºC

Sequence:MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI

uniprot accession:Q9GZX6

Molecular weight:Approximately 33.6 kDa, non-disulfide-linked homodimeric protein containing of two 147 amino acid polypeptide chains.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 5..