Recombinant Human IL-19 protein

SKU: CD01543

Size:2 ug

Background:Human Interleukin-19 (IL-19) is encoded by the IL19 gene, which is located on the chromosome 1. The protein belongs to the IL-10 family that includes IL-10, IL-20, IL-22, IL-24, and IL-26. As a monomer made of seven amphipathic helices, IL-19 has a helical bundle and shares the same cell surface receptor (IL-20R) with IL-20 and IL-24. It may play some important roles in inflammatory responses because it up-regulates IL-6 and TNF-alpha and induces apoptosis.

Research_area:Immunology

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human Interleukin-19

Biological activity:Fully biologically active when compared to standard. The ED5 as determined by a cell proliferation assay using human IL-2Rα and human IL-2Rβ co-transfected Mouse BaF3 pro-B cells is less than 1.5 ng/ml, corresponding to a specific activity of > 6.7 × 15 IU/mg.

Synonyms:IL-19, IL-1C, MDA1, NG.1, ZMDA1,IL19,Human

Endotoxin:Less than 1EU/μg of rHuIL-19 as determined by LAL method.

Storage:-20ºC

Sequence:LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM SSA

uniprot accession:Q9UHD

Molecular weight:Approximately 17.9 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in PBS, pH 7.4.