Recombinant Human IA2/PTPRN Protein (aa 607-Asn686 & aa 795-888, His Tag)

SKU: PKSH032555

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: IA2;PTPRN

Target Synonym: ICA 512;ICA3;ICA512;Islet cell antigen 512;Islet cell autoantigen 3;PTP IA-2;PTPRN;R-PTP-N;Receptor-type tyrosine-protein phosphatase-like N

Research Areas: Signal Transduction;Neuroscience;metabolism;

Conjugation:

Target Species: Human

Expression Host: E.coli

Application:

Fusion tag: N-His

UNIProt ID: Q16849

Accession: Q16849

Background: Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain; is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules; such as their biogenesis; trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity; may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera; and thus may be a potential target of autoimmunity in diabetes mellitus.

Concentration:

Activity: Not validated for activity

Sequence: Gln607-Asn686&Trp795-Leu888

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 8.0.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 22.9 kDa

ObservedMW: 26-30 kDa