Recombinant Human Folate Receptor alpha/FOLR1 (C-6His-Avi) Biotinylated

SKU: PKSH033924

Size: 100μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: Folate Receptor alpha;FOLR1

Target Synonym: Adult folate-binding protein;FBP;FOLR1;FR-alpha;Folate receptor;Folate receptor 1;Folate receptor alpha;Ovarian tumor-associated antigen MOv18

Research Areas: Tags & Cell Markers

Conjugation: Biotinylated

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His-Avi

UNIProt ID: P15328

Accession: P15328

Background: Folate receptor alpha(FOLR) belongs to the folate receptor family, and is primarily expressed in tissues of epithelial origin. It is also expressed in kidney, lung and cerebellum. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. It has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. It is required for normal embryonic development and normal cell proliferation.

Concentration:

Activity: Not validated for activity

Sequence: Arg25-Ser234

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 27.5 kDa

ObservedMW: 35-40 kDa