Recombinant Human Fas Ligand / TNFSF6 (N-6His)

SKU: PKSH033886

Size: 50μg

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation: Fas Ligand;TNFSF6

Target Synonym: APT1LG1CD95L;APTL;Apoptosis antigen ligand;CD178;CD178 antigen;CD95-L;CD95L;FASLCD95 ligand;FASLG;Fas Ligand;Fas antigen ligand;Fas ligand (TNF superfamily;TNFSF6;apoptosis (APO-1) antigen ligand 1;member 6)

Research Areas: Cell biology;immunology;Stem cells

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: N-His

UNIProt ID: P48023

Accession: P48023

Background: Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Concentration:

Activity: Not validated for activity

Sequence: Pro134-Leu281

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 17.7 kDa

ObservedMW: 20-30 kDa