Recombinant Human CD93/C1QR1 Protein (aa 1-580, His Tag)

SKU: PKSH030806

Size: 50μg

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Exp date: 12 months

Category ID_II: Recombinant Proteins

Category ID_III: Others

Abbreviation:

Target Synonym: C1QR1;C1q/MBL/SPA Receptor;C1qR;C1qR(p);C1qRp;CDw93;Complement Component 1 q Subcomponent Receptor 1;Complement Component C1q Receptor;MXRA4;Matrix-Remodeling-Associated Protein 4CD93

Research Areas: Cardiovascular;immunology;Stem cells

Conjugation:

Target Species: Human

Expression Host: HEK293 Cells

Application:

Fusion tag: C-His

UNIProt ID: Q9NPY3

Accession: Q9NPY3

Background: CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes; neutrophils; endothelial cells; and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR; a receptor expressed during early B-cell development; is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive; memory; and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells; including long-lived plasma cells that showed decreased cell cycle activity; high levels of isotype-switched Ig secretion; and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

Concentration:

Activity: Not validated for activity

Sequence: Met 1-Lys 580

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 59.6 kDa

ObservedMW: 100 kDa