Recombinant Human Bcl-xL protein

SKU: CD02273

Size:2 ug

Background:Bcl-xL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays a role in the signal transduction pathway of the FAS-Ligand. Bcl-xL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. It is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. It has cell death repressor activity and therefore acts as a survival protein. The human Bcl-xL shares 97 % a.a. sequence identity with Mouse and rat Bcl-xL.

Research_area: Cell Biology

Purity:> 97 % by SDS-PAGE and HPLC analyses.

Source:Escherichia coli.

Full product name:Recombinant Human B-cell lymphoma-extra large

Biological activity:Test in Process.

Synonyms:Bcl-xL, BCLX; BCL2L; Bcl-X; PPP1R52; BCL-XL/S,Human

Endotoxin:Less than 0.1 EU/μg of rHuBcl-xL as determined by LAL method.

Storage:-20ºC

Sequence:SQSNRELVVD FLSYKLSQKG YSWSQFSDVE ENRTEAPEGT ESEMETPSAI NGNPSWHLAD SPAVNGATGH SSSLDAREVI PMAAVKQALR EAGDEFELRY RRAFSDLTSQ LHITPGTAYQ SFEQVVNELF RDGVNWGRIV AFFSFGGALC VESVDKEMQV LVSRIAAWMA TYLNDHLEPW IQENGGWDTF VELYGNNAAA ESRKGQERFN R

uniprot accession:Q92934

Molecular weight:Approximately 23.7 kDa, a single non-glycosylated polypeptide chain containing 211 amino acids.

Formulation:

Reconstitution:Lyophilized from a .2 μm filtered concentrated solution in 2 mM Tris-HCl, pH 8., 5 % Trehalose.