Recombinant Horse Interleukin-1 Receptor Antagonist protein(IL1RN) (Active)

SKU: CSB-AP003491HO

Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Immunology

Uniprot NO.:O18999

Uniprot Entry Name:IL1RA_HORSE

Gene Names:IL1RN

Species:Equus caballus (Horse)

Source:E.Coli

Expression Region:26-177aa

Sequence:HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VAGYLQESNT KLQEKIDVVP IEPDALFLGL HGRKLCLACV KSGDEIRFQL EAVNITDLSK NKEENKRFTF IRSNSGPTTS FESAACPGWF LCTAQEADRP VSLTNKPKES FMVTKFYLQE DQ

Protein Description:Full Length of Mature Protein

Tag Info:Tag-Free

Mol. Weight:17.4 kDa

Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1?- dependent proliferation of murine D10S cells is less than 3.0 ?g/ml, corresponding to a specific activity of ? 333 IU/mg in the presence of 50 pg/ml rHuIL-1?.

Purity:>95% as determined by SDS-PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:Interleukin-1 receptor antagonist protein Short name: IL-1RN Short name: IL-1ra Short name: IRAP Alternative name(s): IL1 inhibitor

Relevance:Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

PubMed ID:19157767

Function:Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.

Involvement in disease:

Subcellular Location:Secreted

Protein Families:IL-1 family

Tissue Specificity:

Paythway:

HGNC Database Link:

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Eca&CID=13123

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?ecb:100034236

STRING Database Link:https://string-db.org/network/9796.ENSECAP00000004056

OMIM Database Link: