Recombinant HMGCR Monoclonal Antibody

SKU: AN301555L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:HMGCR

Target Synonym:LDLCQ;HMGCR;LDLCQ3;3-hydroxy-3-methylglutaryl-CoA reductase;3-hydroxy-3-methylglutaryl-CoA reductase;LDLCQ3;3-hydroxy-3-methylglutaryl-coenzyme A reductase;HMG-CoA reductase

Research Areas:Cardiovascular;Signal Transduction;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IF;FCM;IP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A254

UNIProt ID:P04035

Accession:

Background:3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein of the endoplasmic reticulum. It is the rate-limiting enzyme for cholesterol biosynthesis and non-sterol isoprenoid biosynthesis. Play a key role in cellular cholesterol homeostasis. The activity of HMGCR is regulated by negative feedback, in which cholesterol and other end products of the metabolic pathway inhibit the activity of HMGCR in a multivalent manner. Cholesterol inhibits reductase activity mainly by inhibiting the transcription rate of HMGCR gene. HMGCR is the main target of statins, which are a class of cholesterol-lowering drugs.

Concentration:1 mg/mL

Immunogen:Recombinant human HMG-CoA Reductase fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IF 1:50;FCM 1:50-1:100;IP 1:25

Calculated MW:97 kDa

ObservedMW:97 kDa