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GeneBio Systems

Recombinant Histone H4 (Mono Methyl Lys12) Monoclonal Antibody

Recombinant Histone H4 (Mono Methyl Lys12) Monoclonal Antibody

AN302114L

$512.44 CAD
$512.44 CAD
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Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies;Acetyl/Phospho/Methyl Antibodies

Abbreviation:Histone H4 (Mono Methyl Lys12)

Target Synonym:H4F;methyl histone H;methylated histone H;HIST2H;HIST1H;HISTH4H;histone H;HIST2H4B;H4/o;histone H4;HIST1H4A;FO108;H4/p;HIST1H4;Hist4h4;HISTH4H4;methyl histone H4;methylated histone H4;H4/A;H4FA;H4/I;H4FI;HIST1H4B;H4/G;H4FG;HIST1H4C;H4/B;H4FB;HIST1H4D;H4/J;H4FJ;HIST1H4E;H4/C;H4FC;HIST1H4F;H4/H;H4FH;HIST1H4H;H4/M;H4FM;HIST1H4I;H4/E;H4FE;H4/D;H4FD;HIST1H4K;H4/K;H4FK;HIST1H4L;H4/N;H4F2;H4FN;HIST2H4;HIST2H4A;H4;H4C1;H4C2;H4C3;H4C4;H4C5;H4C6;H4C8;H4C9;H4C11;H4C12;H4C13;H4C14;H4C15;H4-16;A;I;H4B;H4J;H4H;H4M;H4E;HIST1H4J;H4D;H4C;H4/p;histone H4;HIST1H4B H4/I

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC;IF;FCM;IP;ChIP

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A838

UNIProt ID:P62805

Accession:

Background:The amino-terminal tails of core histones undergo lysine methylation in multiple sites, termed as “histone code” or “epigenetic code”. Lysine methylation in core histones is a major determinant for the formation of active and inactive regions of the genome and therefore plays vital roles in multiple cellular events. In most species, lysine methylation occurs primarily on histones H3 (Lys4, 9, 27, 36, 79) and H4 (Lys5, 8, 12, 20) and has been implicated in both transcriptional activation and silencing. Methylation in histones modulated by specific histone methyltransferases (HMTs) and histone demethylases (HDMs) is impaired in the pathologies of cancer and other diseases and therefore, enzymes regulating histone lysine methylation have become promising targets for anti-cancer drugs.

Concentration:1 mg/mL

Immunogen:Monomethylated human histone H4 (Lys12) peptide

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:2000;IHC 1:100-1:500;IF 1:50-1:200;FCM 1:50;ChIP 6 μg/5×106 cells;IP 1:25-1:50

Calculated MW:11 kDa

ObservedMW:11 kDa

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