Recombinant Glutamate receptor 3 Monoclonal Antibody

SKU: AN301945L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Glutamate receptor 3

Target Synonym:MRX;GRIA;GLUR;GluA;GLUR-K;GRIA3;GLUR-C;GLUR-K3;GLUR3;GLURC;GluA3;MRX94;AMPA 3;AMPA selective glutamate receptor 3;AMPA-selective glutamate receptor 3;dJ1171F9.1;GLUK3;GluR 3;GLUR C;GLUR K3;GluR-3;Glutamate ionotropic receptor AMPA type subunit 3;Glutamate receptor;Glutamate receptor 3;Glutamate receptor C;Glutamate receptor ionotrophic AMPA 3;Glutamate receptor ionotropic;Glutamate receptor subunit 3;GRIA 3;Ionotrophic Glutamate Receptor;ionotropic

Research Areas:Neuroscience;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Rat;Mouse

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A661

UNIProt ID:P42263

Accession:

Background:AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Glutamate receptor 3 (GluR3) knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP). In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission. Aberrant GluR3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Rett's syndrome, amyotrophic lateral sclerosis and Alzheimer disease.

Concentration:1 mg/mL

Immunogen:Recombinant human Glutamate receptor 3 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000

Calculated MW:101 kDa

ObservedMW:101 kDa