Recombinant Estrogen Receptor alpha Monoclonal Antibody

SKU: E-AB-81467

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies

Abbreviation:Estrogen Receptor alpha

Target Synonym:DKFZp686N23123;ER alpha;ER;ER-alpha;Era;ESR;ESR1;ESR1;ESRA;Estradiol receptor;Estrogen nuclear receptor alpha;Estrogen receptor 1;Estrogen receptor alpha 3*;4;5;6;7*/822 isoform;Estrogen receptor alpha;Estrogen receptor alpha delta 3*;4;5;6;7*;8*/941 isoform;Estrogen receptor alpha delta 3*;4;5;6;7*/819 2 isoform;Estrogen receptor alpha delta 4 +49 isoform;Estrogen receptor alpha delta 4*;5;6;7*/654 isoform;Estrogen receptor alpha delta 4*;5;6;7;8*/901 isoform;Estrogen receptor alpha E1 E2 1 2;Estrogen receptor alpha E1 N2 E2 1 2;Estrogen receptor;ESTRR;NR3A1;Nuclear receptor subfamily 3 group A member 1

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Neuroscience;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB;IHC-P;IF

Isotype:IgG

Clonality:Rabbit Monoclonal

Clone NO.:R05-1E4

UNIProt ID:P03372

Accession:

Background:This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Concentration:300 μg/mL

Immunogen:A synthetic peptide of human Estrogen Receptor alpha

Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Purification method:Affinity Purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100;IF 1:20-1:100

Calculated MW:66kDa

ObservedMW:66kDa