Recombinant eIF4G1 Monoclonal Antibody

SKU: AN301953L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:eIF4G1

Target Synonym:PARK;DKFZp686A;eIF 4 gamma;eIF-4-gamma;Eukaryotic translation initiation factor 4 gamma;IF4G;EIF4G1;EIF-4G1;EIF4F;EIF4G;EIF4GI;P220;PARK18;DKFZp686A1451;eIF 4 gamma 1;eIF 4G 1;eIF 4G1;EIF4 gamma;eIF-4G 1;eIF-4-gamma 1;Eukaryotic translation initiation factor 4 gamma 1;IF4G1

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A669

UNIProt ID:Q04637

Accession:

Background:The initiation of translation is an important biological event and a variety of factors contribute to this process. Members of the eIF4 translation initiation factor family bind to the 5' m7GTP mRNA cap and unwind the mRNA secondary structure. The amino-terminal portion of eIF4G physically associates with eIF4E to stimulate the binding of eIF4E to the mRNA cap structure. eIF4G also interacts with eIF3 and eIF4A and serves as an adaptor molecule in the eIF4 complex. Moreover, eIF4G plays a role in internal ribosomal entry site (IRES)-mediated initiation of translation. The eIF4G family includes eIF4G1 (eIF4GI), eIF4G2 (p97, DAP5 or NAT1), and eIF4G3 (eIF4GII). These factors share a homologous sequence that provides for interaction with initiation factors eIF3 and eIF4A. Both eIF4G1 and eIF4G3 are involved in cap-dependent translation, while eIF4G2 plays a role in IRES-mediated translation of some genes during cell stress.

Concentration:1 mg/mL

Immunogen:Recombinant human eIF4G1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000;IHC 1:500-1:1000

Calculated MW:175 kDa

ObservedMW:250 kDa