Recombinant EAAT3 Monoclonal Antibody

SKU: AN302009L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:EAAT3

Target Synonym:EAAC;EAAT;SCZD;SLC1A;SLC1A1;DCBXA;EAAC1;EAAT3;SCZD18;EAA3;EAAC 1;EAAT 3;Excitatory amino acid carrier 1;Excitatory amino acid carrier1;Excitatory amino acid transporter 3;Excitatory amino acid transporter3;Excitatory amino-acid carrier 1;GLUTAMATE TRANSPORTER;HIGH-AFFINITY;MEAAC 1;MEAAC1;member 1;Neuronal and epithelial glutamate transporter;REAAC 1;REAAC1;Slc1 a1;Slc1a 1;Sodium dependent glutamate/aspartate transporter 3;Sodium-dependent glutamate/aspartate transporter 3;Solute carrier family 1;Solute carrier family 1 (neuronal / epithelial high affinity glutamate transporter;Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter;SOLUTE CARRIER FAMILY 1 (NEURONAL/EPITHELIAL HIGH AFFINITY GLUTAMATE TRANSPORTER);Solute carrier family 1 member 1;system Xag)

Research Areas:Neuroscience

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A729

UNIProt ID:P43005

Accession:

Background:During neurotransmission, glutamate is released from vesicles of the presynaptic cell, and glutamate receptors (e.g., NMDA Receptor, AMPA Receptor) bind glutamate for activation at the opposing postsynaptic cell. Excitatory amino acid transporters (EAATs) regulate and maintain extracellular glutamate concentrations below excitotoxic levels. In addition, glutamate transporters may limit the duration of synaptic excitation by an electrogenic process in which the transmitter is cotransported with three sodium ions and one proton, followed by countertransport of a potassium ion. Five EAATs (EAAT1-5) have been identified. EAAT1 and EAAT2 are expressed mainly in glia, while EAAT3, EAAT4, and EAAT5 are considered to be neuronal transporters. EAAT3 is found in the perisynaptic areas and cell bodies of glutamatergic and GABAergic neurons. Research studies have implicated abnormal EAAT3 expression in the pathophysiology of Schizophrenia.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000;IHC 1:500-1:1000

Calculated MW:57 kDa

ObservedMW:70 kDa