Recombinant DcR1 Monoclonal Antibody

SKU: AN301996L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:DcR1

Target Synonym:DCR;UNQ;PRO;TRAILR;TRAIL-R;TNFRSF10C;CD263;DCR1;DCR1-TNFR;LIT;TRAIL-R3;TRAILR3;TRID;UNQ321;PRO366;DcR1;TRID;TNFRSF10c;Antagonist Decoy Receptor for TRAIL/Apo-2L;Decoy Receptor 1;Decoy TRAIL Receptor Without Death Domain;Lymphocyte Inhibitor of TRAIL;TNF-Related Apoptosis-Inducing Ligand Receptor 3;TRAIL Receptor 3;TRAIL Receptor Without an Intracellular Domain;Tumor Necrosis Factor Receptor Superfamily Member 10C

Research Areas:Cell Biology;Immunology;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;

Application:WB;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A716

UNIProt ID:O14798

Accession:

Background:The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems.The receptors are activated by a family of cytokines that include TNF, FasL, and TNF-related apoptosis-inducing ligand (TRAIL). They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain (DD). The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins (FADD, TRADD, RIP) to the death-inducing signaling complex (DISC), resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors (DcR1, DcR2, and DcR3) which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.

Concentration:1 mg/mL

Immunogen:Peptide. This information is proprietary to PTMab.

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:1000-1:2000;IF 1:50

Calculated MW:27 kDa

ObservedMW:27, 80-100 kDa