Recombinant Cyclin D1 Monoclonal Antibody

SKU: AN301028L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Cyclin D1

Target Synonym:Cyl;PRAD;U21B;CCND;B cell leukemia;G1/S specific cyclin D;Cyclin D;BCL;BCL1;D11S287E;PRAD1;U21B31;CCND1;Cyclin D1;B cell leukemia 1;BCL 1;Cd1;Cyl 1;G1/S specific cyclin D1;BCL1;D11S287E;PRAD1;U21B31;CCND1;Cyclin D1;cyclin D1

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:5A3

UNIProt ID:P24385

Accession:

Background:The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Cyclin D1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:200-1:1000;WB 1:1000-1:5000

Calculated MW:34 kDa

ObservedMW:36 kDa