Recombinant Clusterin beta Chain Monoclonal Antibody

SKU: AN301900L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:Clusterin beta Chain

Target Synonym:KUB;AAG;Ku70-binding protein;Sulfated glycoprotein;Complement-associated protein SP;Testosterone-repressed prostate message;NA1/NA;SGP;CLU;AAG4;APO-J;APOJ;CLI;CLU1;CLU2;KUB1;NA1/NA2;SGP-2;SGP2;SP-40;TRPM-2;TRPM2;clusterin;CLUS;Aging-associated gene 4 protein;Apolipoprotein J;Complement cytolysis inhibitor;Complement-associated protein SP-40;Ku70-binding protein 1;Sulfated glycoprotein2;Testosterone-repressed prostate message 2;Complement cytolysis inhibitor a chain;Clusterin alpha chain;Complement cytolysis inhibitor b chain;APOJ CLI;Sulfated glycoprotein 2

Research Areas:Immunology;Cardiovascular;Signal Transduction;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Rat;Mouse

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A616

UNIProt ID:P10909

Accession:

Background:Clusterin (CLU) also named as apolipoprotein J, is a multifunctional glycoprotein that is expressed ubiquitously in most tissues. Clusterin functions as a secreted chaperone protein that interacts with and stabilizes stress-induced proteins to prevent their precipitation. Research studies show that clusterin plays a protective role in Alzheimer’s disease by sequestering amyloid β (1-40) peptides to form long-lived, stable complexes, which prevents amyloid fibril formation.In addition to the secreted protein, several intracellular isoforms are localized to the nucleus, mitochondria, cytoplasm and ER. The subcellular distribution of these multiple isoforms leads to the diversity of clusterin functions. Additional studies report that clusterin is involved in membrane recycling, cell adhesion, cell proliferation, apoptosis, and tumor survival.

Concentration:1 mg/mL

Immunogen:Recombinant human Clusterin beta Chain fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000

Calculated MW:52 kDa

ObservedMW:35 kDa