Recombinant Caspase-3 Monoclonal Antibody

SKU: AN301377L

Size::

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Caspase-3

Target Synonym:SCA;CPP;Caspase-3 p;SREBP cleavage activity;Caspase;Caspase-;CPP32;CPP32B;SCA-1;Active Caspase 3;CASP3;active Caspase-3;Caspase 3;Caspase-3 p12;caspase-3;Apoptain;Yama;CASP-3;Apopain;Protein Yama;SREBP cleavage activity 1;Caspase-3 subunit p17;Caspase-3 subunit p12;caspase-3;CPP32;CPP32B;SCA-1;A830040C14Rik;apoptosis-related cysteine peptidase;apoptosis-related cysteine protease;apoptosis-related cysteine protease a;Casp3a;CC3;CPP-32;Cysteine protease CPP32;EC 3.4.22.56;LICE;mldy;OTTHUMP00000165052;OTTHUMP00000165053;OTTHUMP00000165054;PARP cleavage protease;Procaspase3;SCA 1

Research Areas:Neuroscience;Cell Biology;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:6F7

UNIProt ID:P42574

Accession:

Background:This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Caspase-3 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:WB 1:1000-5000

Calculated MW:31.6 kDa

ObservedMW:35 kDa