Recombinant Bmi-1 Monoclonal Antibody

SKU: AN301273L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Recombinant Antibodies;Monoclonal Antibodies

Abbreviation:Bmi-1

Target Synonym:RNF;BMI;PCGF;flvi-2/bmi;FLVI2/BMI;BMI1;FLVI2/BMI1;PCGF4;RNF51;flvi-2/bmi-1;Bmi-1

Research Areas:Cell Biology;Epigenetics and Nuclear Signaling;Stem Cells;Cancer

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:7B9

UNIProt ID:P35226

Accession:

Background:BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

Concentration:0.2 mg/mL

Immunogen:Recombinant Human Bmi-1 protein

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A

Dilution:IHC 1:100-1:500

Calculated MW:

ObservedMW: