Recombinant AKT1 Monoclonal Antibody

SKU: AN301428L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:AKT1

Target Synonym:CWS;MGC;AKT serine/threonine kinase;AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA;AKT1;AKT 1;AKT serine/threonine kinase 1;AKT1_HUMAN;MGC99656;Protein kinase B;Protein Kinase B Alpha;Proto-oncogene c-Akt;RAC Alpha;RAC-alpha serine/threonine-protein kinase;RAC-PK-alpha;AKT;AKT serine/threonine kinase 1;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA

Research Areas:Signal Transduction;Epigenetics and Nuclear Signaling;Cancer;Metabolism;Neuroscience

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat;Mouse

Application:WB;IHC

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A123

UNIProt ID:P31749

Accession:

Background:The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

Concentration:1 mg/mL

Immunogen:Recombinant human AKT1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IHC 1:50-1:100

Calculated MW:60 kDa

ObservedMW:60 kDa