Recombinant ABCE1 Monoclonal Antibody

SKU: AN301424L

Size::50μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies;Recombinant Antibodies

Abbreviation:ABCE1

Target Synonym:ABC;ABCE;RNASEL;OK/SW-cl;ABCE1;ABC38;OABP;RLI;RLI1;RNASEL1;RNASELI;RNS4I;OK/SW-cl.40;2' 5' oligoadenylate binding protein;2'5' oligoadenylate binding protein;2''-5''-oligoadenylate-binding protein;ABC 38;ABCE 1;ATP binding cassette sub family E (OABP) member 1;ATP binding cassette sub family E member 1;ATP-binding cassette sub-family E member 1;HuHP 68;HuHP68;Ribonuclease 4 inhibitor;Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor;Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor;Ribonuclease L inhibitor;RNase L inhibitor;RNS 4I

Research Areas:Signal Transduction;Immunology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB;IF

Isotype:IgG,κ

Clonality:Monoclonal;Recombinant

Clone NO.:A119

UNIProt ID:P61221

Accession:

Background:Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Plays a role in the regulation of mRNA turnover. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway.

Concentration:1 mg/mL

Immunogen:Recombinant human ABCE1 fragment

Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Purification method:Protein A purified

Dilution:WB 1:500-1:1000;IF 1:50

Calculated MW:34 kDa

ObservedMW:45 kDa