RCC2 rabbit pAb

SKU: ES6811

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Mouse

Dilution:Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human RCC2. AA range:473-522

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):56kD

Human_gene_id:55920

Human_swiss_prot_no:Q9P258

Subcellular_location:Nucleus, nucleolus . Nucleus . Cytoplasm, cytoskeleton . Chromosome, centromere . Cytoplasm, cytoskeleton, spindle . Chromosome . Midbody . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex (PubMed:12919680, PubMed:1939370, PubMed:7559776, PubMed:9914378). Colocalizes with cytoplasmic microtubules in interphase cells (PubMed:23388455). Colocalizes with RAC1 at the cell membrane (PubMed:25074804). .

Other_name:RCC2; KIAA1470; TD60; Protein RCC2; RCC1-like protein TD-60; Telophase disk protein of 60 kDa

Background:function:Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 7 RCC1 repeats.,subcellular location:Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.,subunit:Binds preferentially to the nucleotide-free form of RAC1. Interacts with microtubules.,