Rat Voltage Dependent Anion Channel Protein 1,VDAC1 ELISA KIT

SKU: E2889Ra

Size:96 Tests-1 Kit

Background:Forms a channel through the mitochondrial outer membrane and also the plasma membrane (By similarity). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (By similarity). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:25628567). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (By similarity). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (By similarity). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity). May mediate ATP export from cells (By similarity). {ECO:0000250|UniProtKB:P21796, ECO:0000269|PubMed:25628567}.

Research_area:

Applications:ELISA

Target_protein:Vdac1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:6.93ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Voltage Dependent Anion Channel Protein 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Z2L0

MASS(Da):30756

GeneID:83529

Synonyms:Vdac1

Gene names:Vdac1

Standard solution:3200ng/L