Rat Vascuoar Endothelial Cell Growth Factor Receptor 2, VEGFR-2 ELISA Kit

SKU: E0664Ra

Size:96 Tests-1 Kit

Background:Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC (By similarity).

Research_area:Cancer

Applications:ELISA

Target_protein:KDR

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.21ng/mL

Detection range:0.5-200ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Vascuoar Endothelial Cell Growth Factor Receptor 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O08775

MASS(Da):150,394

GeneID:25589

Synonyms:CD antigen CD309;Fetal liver kinase 1;FLK-1;KDR;Protein-tyrosine kinase receptor flk-1;Vascular endothelial growth factor receptor 2;VEGFR-2

Gene names:KDR

Standard solution:240ng/mL