Rat Udp-Glucuronosyltransferase 2B7, UGT2B7 ELISA Kit

SKU: E2314Ra

Size:96 Tests-1 Kit

Background:UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol,catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent.

Research_area:Others

Applications:ELISA

Target_protein:UGT2B7

Reactivity:Rat

Assay type:Sandwich

Sensitivity:4.66ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:UDP-glucuronosyltransferase 2B7

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q62789

MASS(Da):60,089

GeneID:286989

Synonyms:UDP-glucuronosyltransferase 2B7;UDPGT 2B7;UGT2B7;Ugt2b8;UGT2B-RH4

Gene names:Ugt2b7

Standard solution:2400ng/L