Rat Transient Receptor Potential Cation Channel Subfamily V, Member 1, TRPV1 ELISA Kit

SKU: E1568Ra

Size:96 Tests-1 Kit

Background:Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis. Does not display channel activity in response to noxious chemical compounds, such as capsaicin and the vanilloid resiniferatoxin. Channel activity is not elicited by mildly acidic extracellular pH, and only slight channel activity is observed in response to noxiuos heat stimuli.

Research_area:Neuroscience

Applications:ELISA

Target_protein:TRPV1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:7.13ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Transient Receptor Potential Cation Channel Subfamily V, Member 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35433

MASS(Da):94,948

GeneID:83810

Synonyms:Capsaicin receptor;Osm-9-like TRP Channel 1;OTRPC1;Transient receptor potential cation Channel subfamily V member 1;TRPV1;TRPV1_SON;Vanilloid receptor 1;Vanilloid receptor type 1-like;VR.5'sv;Vr1;Vr1l1

Gene names:Trpv1

Standard solution:3200ng/L