Rat Transient receptor potential cation channel subfamily M member 4,Trpm4 ELISA KIT

SKU: E2929Ra

Size:96 Tests-1 Kit

Background:Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells (By similarity). Plays a role in keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q7TN37, ECO:0000250|UniProtKB:Q8TD43, ECO:0000269|PubMed:16966582, ECO:0000269|PubMed:19945433}.

Research_area:

Applications:ELISA

Target_protein:Trpm4

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.19ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9ESQ5

MASS(Da):135341

GeneID:171143

Synonyms:Trpm4 Ltrpc4

Gene names:Trpm4

Standard solution:48ng/ml