Rat Tissue Inhibitors of Metalloproteinase 1, TIMP-1 ELISA Kit

SKU: E0322Ra

Size:96 Tests-1 Kit

Background:Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:TIMP1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.02ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Tissue Inhibitors of Metalloproteinase 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P30120

MASS(Da):23,794

GeneID:116510

Synonyms:Metalloproteinase inhibitor 1;TIMP 1;TIMP1;TIMP-1;Tissue inhibitor of metalloproteinases 1

Gene names:TIMP1

Standard solution:16ng/ml