Rat Thyroxine, T4 ELISA Kit

SKU: EA0027Ra

Size:96 Tests-1 Kit

Background:Thyroid hormones are two hormones produced and released by the thyroid gland, namely triiodothyronine (T3) and thyroxine (T4). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T3 and T4 are partially composed of iodine. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as simple goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. In humans, the ratio of T4 to T3 released into the blood is approximately 14:1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5′-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:T4

Reactivity:Rat

Assay type:Competitive

Sensitivity:1.25ng/ml

Detection range:2 - 600ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Thyroxine

Species:Rat

Storage:2-8ºC

Assay time:2h 30m

UniProt accession:

MASS(Da):

GeneID:

Synonyms:T4;Thyroxine

Gene names:T4

Standard solution:640ng/ml