Rat Rho-associated Protein Kinase 2, ROCK2 ELISA Kit

SKU: E2239Ra

Size:96 Tests-1 Kit

Background:Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

Research_area:Cell Biology

Applications:ELISA

Target_protein:ROCK2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:14.56ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Rho-associated protein kinase 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q62868

MASS(Da):160,387

GeneID:25537

Synonyms:p150 ROK-alpha;p164 ROCK-2;RhoA-binding kinase 2;Rho-associated protein kinase 2;Rho-associated, coiled-coil-containing protein kinase 2;Rho-associated, coiled-coil-containing protein kinase II;ROCK2;ROCK-II;ROK;ROKalpha

Gene names:Rock2

Standard solution:9600ng/L