Rat Prostaglandin reductase 1,PTGR1 ELISA KIT

SKU: E0945Ra

Size:96 Tests-1 Kit

Background:NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) (By similarity). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha (PubMed:11524419) (By similarity). Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). Plays a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one (PubMed:11524419). Inactivates 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (PubMed:11524419). {ECO:0000250|UniProtKB:Q14914, ECO:0000250|UniProtKB:Q29073, ECO:0000269|PubMed:11524419}.

Research_area:

Applications:ELISA

Target_protein:Ptgr1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.09ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Prostaglandin reductase 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P97584

MASS(Da):35718

GeneID:192227

Synonyms:Ptgr1 Dig1 Ltb4dh

Gene names:Ptgr1

Standard solution:24ng/ml