Rat Progranulin, PGRN ELISA Kit

SKU: E1222Ra

Size:96 Tests-1 Kit

Background:Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (By similarity). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (By similarity). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (By similarity). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (By similarity). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (By similarity). [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.

Research_area:Neuroscience; Immunology

Applications:ELISA

Target_protein:GRN

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.26ng/ml

Detection range:0.5-200ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Progranulin

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23785

MASS(Da):63,370

GeneID:29143

Synonyms:Acrogranin;Epithelin precursor;Epithelin-1;Epithelin-2;Granulin A;Granulin B;Granulin C;Granulin D;Granulin E;Granulin F;Granulin G;Granulin precursor;Granulin-1;Granulin-2;Granulin-3;Granulin-4;Granulin-5;Granulin-6;Granulin-7;GRN;Paragranulin;PEPI;PGRN;Proepithelin;Progranulin

Gene names:GRN

Standard solution:240ng/ml