Rat Programmed Cell Death Protein 6, PDCD6 ELISA Kit

SKU: E1730Ra

Size:96 Tests-1 Kit

Background:Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (By similarity). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (By similarity). Involved in ER-Golgi transport (PubMed: 27276012). Regulates ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (By similarity). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (By similarity). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (By similarity). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (By similarity). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (By similarity). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (By similarity). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (By similarity). [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:PDCD6

Reactivity:Rat

Assay type:Sandwich

Sensitivity:1.63ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Programmed Cell Death Protein 6

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:G3V7W1

MASS(Da):21,905

GeneID:308061

Synonyms:ALG-2;Apoptosis-linked gene 2 protein homolog;PDCD 6;PDCD6;Programmed cell death protein 6

Gene names:PDCD6

Standard solution:960ng/L