Rat Neurogenic locus notch homolog protein 2,NOTCH2 ELISA KIT

SKU: E1107Ra

Size:96 Tests-1 Kit

Background:Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells (By similarity). {ECO:0000250|UniProtKB:O35516, ECO:0000250|UniProtKB:Q04721}.

Research_area:

Applications:ELISA

Target_protein:Notch2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.09ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neurogenic locus notch homolog protein 2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9QW30

MASS(Da):265370

GeneID:

Synonyms:Notch2

Gene names:Notch2

Standard solution:24ng/ml