Rat Multidrug Resistance-associated Protein 1, ABCC1 ELISA Kit

SKU: E2156Ra

Size:96 Tests-1 Kit

Background:Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency (PubMed: 15129170). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed: 17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

Research_area:Signal Transduction; Cancer; Cardiovascular; Metabolism

Applications:ELISA

Target_protein:ABCC1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:5.45ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Multidrug Resistance-Associated Protein 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8CG09

MASS(Da):171,493

GeneID:24565

Synonyms:ABCC 1;ABCC1;ATP-binding cassette sub-family C member 1;Glutathione-S-conjugate-translocating ATPase ABCC1;Leukotriene C(4 transporter;LTC4 transporter;Multidrug resistance-associated protein 1

Gene names:ABCC1

Standard solution:2400ng/L