Rat Mitofusin-2,MFN2 ELISA KIT

SKU: E2857Ra

Size:96 Tests-1 Kit

Background:Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:14561718, PubMed:15322553, PubMed:12589796, PubMed:12598526). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (PubMed:12598526). Plays an important role in the regulation of vascular smooth muscle cell proliferation (PubMed:15322553). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (By similarity). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). {ECO:0000250|UniProtKB:O95140, ECO:0000250|UniProtKB:Q80U63, ECO:0000269|PubMed:12589796, ECO:0000269|PubMed:12598526, ECO:0000269|PubMed:14561718, ECO:0000269|PubMed:15322553}.

Research_area:

Applications:ELISA

Target_protein:Mfn2

Reactivity:Rat

Assay type:Sandwich

Sensitivity:9.33ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Mitofusin-2

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8R500

MASS(Da):86123

GeneID:

Synonyms:Mfn2 Fzo1a

Gene names:Mfn2

Standard solution:8000ng/L