Rat Fractalkine, FK ELISA Kit

SKU: E1968Ra

Size:96 Tests-1 Kit

Background:Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:CX3CL1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.053ng/mL

Detection range:0.1-40ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Fractalkine

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O55145

MASS(Da):41,977

GeneID:89808

Synonyms:CX3C membrane-anchored chemokine;C-X3-C motif chemokine 1;CX3CL1;Fractalkine;Neurotactin;Processed fractalkine;Small-inducible cytokine D1

Gene names:CX3CL1

Standard solution:48ng/mL