Rat Formin-binding protein 1,FNBP1 ELISA KIT

SKU: E0981Ra

Size:96 Tests-1 Kit

Background:Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL (By similarity). May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Isoform 1 and isoform 2 promote RND2-induced neurite branching in neuronal cells. {ECO:0000250, ECO:0000269|PubMed:12244061, ECO:0000269|PubMed:14732713}.

Research_area:

Applications:ELISA

Target_protein:Fnbp1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.11ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Formin-binding protein 1

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8R511

MASS(Da):71293

GeneID:192348

Synonyms:Fnbp1 Fbp17

Gene names:Fnbp1

Standard solution:24ng/ml