Rat Disrupted in schizophrenia 1 protein,DISC1 ELISA KIT

SKU: E6287Ra

Size:96 Tests-1 Kit

Background:Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17035248). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (By similarity). {ECO:0000250|UniProtKB:Q811T9, ECO:0000250|UniProtKB:Q9NRI5, ECO:0000269|PubMed:17035248}.

Research_area:

Applications:ELISA

Target_protein:Disc1

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.06ng/ml

Detection range:0.13-8ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Disrupted in schizophrenia 1 protein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q810H6

MASS(Da):92563

GeneID:307940

Synonyms:Disc1

Gene names:Disc1

Standard solution:16ng/ml