Rat Alpha-Synuclein, SNCA ELISA Kit

SKU: E1113Ra

Size:96 Tests-1 Kit

Background:Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.

Research_area:Neuroscience

Applications:ELISA

Target_protein:SNCA

Reactivity:Rat

Assay type:Sandwich

Sensitivity:0.15ng/ml

Detection range:0.5-100ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Alpha-Synuclein

Species:Rat

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P37377

MASS(Da):14,515

GeneID:29219

Synonyms:Alpha-synuclein;SNCA

Gene names:SNCA

Standard solution:128ng/ml