RAG2 Monoclonal Antibody

SKU: BT-MCA3435

Size:100μL

Background:This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Research_area:Epigenetics and nuclear signaling

Target_protein:RAG2

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:4D5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:RAG2

Immunogen:Purified recombinant fragment of human RAG2(350-527aa) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):59kDa

UniProt accession:P55895

Synonyms:RAG-2, RAG2

GeneID:5897