RAD50 Antibody - Cat. #: CSB-PA589951

SKU: CSB-PA589951

Size :100ul

Clone Number:

Aliases:DNA repair protein RAD50 antibody; hRAD50 antibody; hsRAD50 antibody; Mrell antibody; NBSLD antibody; Rad 50 antibody; RAD50 2 antibody; rad50 antibody; RAD50 homolog (S cerevisiae) antibody; RAD50 homolog antibody; RAD50 PEN antibody; RAD50, S. cerevisiae, homolog of antibody; RAD50_HUMAN antibody; RAD502 antibody; Rad50l antibody; Truncated RAD50 protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q92878

Immunogen:Synthesized peptide derived from internal of Human RAD50.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Dolganov G.M., Mol. Cell. Biol. 16:4832-4841(1996).
Kim K.K., Gene 235:59-67(1999).
Carney J.P., Cell 93:477-486(1998).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RAD50

Research Areas:Epigenetics and Nuclear Signaling