RAD21 Antibody - Cat. #: CSB-PA590651

SKU: CSB-PA590651

Size :100ul

Clone Number:

Aliases:CDLS4 antibody; Double-strand-break repair protein rad21 homolog antibody; hHR21 antibody; HR21 antibody; HRAD21 antibody; KIAA0078 antibody; MCD1 antibody; Nuclear matrix protein 1 antibody; NXP-1 antibody; NXP1 antibody; Protein involved in DNA double-strand break repair antibody; RAD21 antibody; RAD21 homolog (S. pombe) antibody; RAD21 homolog antibody; RAD21_HUMAN antibody; Scc1 antibody; SCC1 homolog antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O60216

Immunogen:Synthesized peptide derived from internal of Human RAD21.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

McKay M.J., Genomics 36:305-315(1996).
Sadano H., Biochem. Biophys. Res. Commun. 267:418-422(2000).
Nomura N., DNA Res. 1:223-229(1994).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RAD21

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology