RAC1 Antibody, FITC conjugated - Cat. #: CSB-PA04329C0Rb

SKU: CSB-PA04329C0Rb

Size :50ug

Clone Number:

Aliases:Cell migration inducing gene 5 protein antibody; Cell migration-inducing gene 5 protein antibody; MGC111543 antibody; MIG5 antibody; Migration inducing gene 5 antibody; Migration inducing protein 5 antibody; p21 Rac1 antibody; p21-Rac1 antibody; Rac 1 antibody; RAC1 antibody; RAC1_HUMAN antibody; Ras like protein TC25 antibody; Ras related C3 botulinum toxin substrate 1 (rho family; small GTP binding protein Rac1) antibody; Ras-like protein TC25 antibody; Ras-related C3 botulinum toxin substrate 1 antibody; Rho family small GTP binding protein Rac1 antibody; TC 25 antibody; TC25 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P63000

Immunogen:Recombinant Human Ras-related C3 botulinum toxin substrate 1 protein (11-185AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:RAC1

Research Areas:Cancer; Immunology; Signal transduction