RAB8A antibody , Cat. # FNab07045

SKU: FNab07045

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites(AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.

Immunogen:RAB8A, member RAS oncogene family

Synonyms:MEL, Oncogene c mel, RAB8, RAB8A, Ras related protein Rab 8A

Observed MW:24 kDa

Uniprot ID:P61006

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IF, IP

Recommended dilution:WB: 1:500-1:5000; IP: 1:200-1:2000; IF: 1:10-1:100

Gene ID:4218

Research Area:Signal Transduction